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A transparent wound dressing based on bacterial cellulose whiskerand poly(2-hydroxyethyl methacrylat
Date: 2017-08-08
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Essay topic:A transparent wound dressing based on bacterial cellulose whiskerand poly(2-hydroxyethyl methacrylate)

AmbitGeneral polymer materials

Author:Zeng Dia,b,1, Zhijun Shia,b,1, Muhammad Wajid Ullaha,b, Sixiang Lia,b, Guang Yanga,b,.

Key words:BC whisker、Hydrogel、Antibacterial properties、Transparent wound dressinga

Source: Biological Macromolecules

Specific source :

Access route:http://dx.doi.org/10.1016/j.ijbiomac.2017.07.075

Published:2017.7.12

Abstract:

The current study was aimed to develop a transparent wound dressing comprised of bacterial cellulose(BC) and poly (2-hydroxyethyl methacrylate) (PHEMA) hydrogel coated with silver (Ag) nanoparticles.Briefly, different concentrations of BC whiskers (BCWs) were added into the HEMA solution to formPHEMA/BCWs hydrogel with volume ratio of monomer HEMA and BCWs as 7:3 and 1:1. The addition ofBCWs into PHEMA matrix improved its equilibrium water content and light transmittance about 20%-40%and 10%, respectively. The Young’s modulus for PHEMA was found to be 0.72 MPa, which was improvedto 0.57 MPa and 0.50 MPa for PHEMA/BCWs 7:3 and PHEMA/BCWs 1:1, respectively. Further, immersionof PHEMA/BCWs hydrogel in the AgNO3and NaBH4solutions bestowed it with antibacterial property andproduced inhibition zones of 0.5 ± 0.15 cm and 0.25 ± 0.15 cm against Escherichia coli and Staphylococcusaureus, respectively. Similarly, PHEMA/BCWs prepared with 0.001 M AgNO3and 0.001 M NaBH4solutionsshowed 99% and 90% reduction in colony forming unit (CFU) for E. coli and S. aureus, respectively, after 24 h.The PHEMA/BCWs/Ag hydrogel facilitated the growth of NIH3T3 fibroblast, showing their low toxicity.These results demonstrate the suitability of PHEMA/BCWs/Ag hydrogel for its application as potentialtransparent wound dressing material for skin repair.

 

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 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu Address: College of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu East  


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