1. Bacterial Cellulose as a Supersoft Neural Interfacing Substrate. ACS applied materials & interfaces 2018, 10, 33049-33059.

Biocompatible neural interface materials are of great significance in the treatment of neurological disorders and enhancement of patients' mental and physiological functions. Currently, the elastic modulus of commonly used neural interface materials is much higher than that of human nerve tissues, and the mismatch of elastic modulus will lead to inflammation in the implanted area.
Long-term unfavorable to neural signals collected. Yang guang and others with good biocompatibility and flexibility of bacterial cellulose as the base, the preparation of surplus flexible multi-channel neural electrode, the material has a lower young's modulus (120 kPa), between cranial nerve (2.7-3. 1 kPa) and peripheral nerve (580-840 kPa), under the condition of repeated folding bending with good electric conductivity (figure 24), implanted in rat cortical neural signals collected with good signal-to-noise ratio, long-term implantation can avoid to produce severe inflammation reaction.
These Interfaces have important potential applications in neural interface Materials (ACS Applied Materials & Interfaces 2017, 9, 32545-32553).

2. Reverse Reconstruction and Bioprinting of Bacterial Cellulose Based Functional Total Intervertebral Disc for Therapeutic Implantation. Small, 2017, 201702582;

At present, the main challenge of tissue-engineered artificial intervertebral discs is to simulate the unique anisotropy structure of the annulus fibrosus to prepare a complete intervertebral disc with nucleus pulposus and annulus fibrosus.
Yang Guang et al. proposed a strategy for reverse reconstruction of 3d artificial intervertebral discs with complex anisotropic structures from 2D to 3D.
First design by using microfluidic channel induction of wood vinegar coli form a two-dimensional orderly bacterial cellulose (BC), the level of two-dimensional BC surface has 30 o + and - 30 o and white pattern, then the 2 d micro pattern BC was formed by curled around the circular shaft structure of concentric rings, each ring with the same orientation, and the adjacent two ring micro pattern respectively arranged along the direction of 30 o + or + 30 o, copied fiber ring structure in the body.
This method of reverse reconstruction provides a new strategy for constructing complex anisotropic human tissues (Small.2017, 1702582).

3. Biomimetic Nanofibers Can Construct Effective Tissue-Engineered Intervertebral Disc for Therapeutic Implantation. Nanoscale, 2017, 9, 13095-13103;

Functional and histocompatibility evaluation of artificial intervertebral disc implant prostheses based on polycaprolactone (PCL)/Poly (D, L-Lactide-co-Glycolide)/I blended ordered static spinning (PLGA) (Collagen Type I (PPC)) and Collagen type I (PPC) fibers with anisotropic spin and nucleus pulposus based on sodium alginate gel.
The fiber ring constructed by orderly PPC spinning can not only simulate the anisotropy structure of intervertebral disc in vivo, i.e.
Each ring of the concentric ring fiber rings is arranged in an orderly manner, and the fibers of the adjacent rings are arranged alternately as +/ -30o.
Nano-scale ordered PPC spinning can induce 79.2% fibro-ring cells to achieve highly ordered arrangement, and PPC spinning has strong hydrophilicity, high water retention and degradability.
Long-term in vivo implantation measurements have demonstrated the excellent performance of tissue-engineered intervertebral discs.
This study provides a new strategy for the construction of three-dimensional artificial intervertebral discs and other anisotropic tissues or organs (Nanoscale.2017, 9, 13095-13103)