2019.8.27.Professor Feng Chuanliang, School of Material Science and Engineering, Shanghai Jiaotong University, was invited by Professor Yang Guang to visit the College of Life Science and Technology and give an academic report on biomimetic chiral supramolecular hydrogels. 

Feng Chuanliang, Professor and Vice-Dean, School of Materials Science and Engineering, Shanghai Jiaotong University. In 2005, Twente University of the Netherlands received a doctoral degree. In 2009, he was employed as a professor at Shanghai Jiaotong University. He has been selected as "Excellent Talents Plan for the New Century" by the Ministry of Education, "Special Professors of Universities (Oriental Scholars) in Shanghai, and"Pujiang Talents"in Shanghai. It undertakes more than 20 major projects such as the National Natural Science Foundation of China and the Shanghai Municipal Education Commission. The research direction is hydrogel biomaterials, which mainly solves the fundamental problem of chirality in biomimetic extracellular microenvironment, explores the mechanism and essence of chiral structure on cell adhesion, growth and differentiation, and provides theoretical and technical support for tissue engineering and biomedicine based on biomimetic microenvironment. More than 110 papers have been published in J.Am.Chem.Soc., Adv.Mater., Angew.Chem.Int.Ed., Adv.Funct.Mater.ACSNano, Small and other international mainstream academic journals. It has been used as cover for many times by Angew. Chem. Int. Ed., Small and other periodicals. Write papers by Adv. Mater. As Editorial Board of Advanced Composite and Hybrid Materials, etc. More than 10 patents have been applied for.

  Hydrogel is one of the best biomimetic extracellular matrix (ECM). ECM is a network structure that supports and connects tissues. It mainly regulates the occurrence of tissues and the physiological activities of cells. The chiral characteristics of ECM play a decisive role. However, the research on chiral regulation of tissue cells by ECM is still in the exploratory stage, and it affects cell adhesion. The nature and mechanism of attachment and growth is still a key scientific problem to be solved urgently. To carry out relevant research can not only understand the origin of stereoselectivity in life system, but also have application value in biomedical health and other fields. The key to solve this problem is how to design molecular structure to construct chiral biomimetic hydrogels and study their interaction with cells and biomolecules. In order to solve the above scientific problems, our research group has introduced the idea of functionalization into the design of Supramolecular Gel molecular structure in the past few years. We synthesized a series of chiral supramolecular gel factors based on C2 symmetry. Rice fiber self-assembly has a maximum moisture content of 99.94%. It has a porous structure of 10-80 micron. The diameter of nanofibers is between 10-300 nanometers, which meets the needs of cell growth space. Based on the basic and applied research of chiral hydrogel materials, the design idea of chiral center gel was proposed, and the principles and methods of long-range chiral hydrogels were discovered, which gave the chiral controllable characteristics of hydrogels, and revealed the selective rule of the interaction between cells and chiral nanostructures. The theoretical basis of the importance of chiral structure in tissue engineering is explored. The characteristics of the multiple functions of chiral hydrogel are explored. The application and development of extracellular culture matrix based on chiral hydrogel are guided. It provides new ideas and methods for the research of tissue engineering based on chiral biomimetic microenvironment.