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Enrollment Publications
Evaluation of the effect of the structure of bacterial cellulose on full thickness skin wound repair
Date: 2017-06-08
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Essay topic:Evaluation of the effect of the structure of bacterial cellulose on full thickness skin wound repair on a microfluidic chip

AmbitFunctional polymer

Author:Ying Li ,Shiwen Wang,Rong Huang,Zhuo Huang,Binfeng Hu,Wenfu Zheng* , Guang Yang* , and Xingyu Jiang*

Key words:Bacterial cellulose,skin wound,microfluidic chip

Source: journal

Specific source :Biomacromolecules

Published:

Abstract:2015.01

Bacterial cellulose (BC) is a kind of nano-biomaterials for tissue engineering. How the nanoscale structure of BC affects skin wound repair is unexplored. Here, the hierarchical structure of BC film and their different effects on skin wound healing were studied both in vitro and in vivo. The bottom side of the BC film had a larger pore size, looser and rougher structure than that of the top side. By using a microfluidics-based in vitro wound healing model, we revealed that the bottom side of the BC film can better promote the migration of cells to facilitate wound healing. Furthermore, the full-thickness skin wounds on Wistar rats demonstrated that, compared with gauze and top side of the BC film, the wound covered by the bottom side of the BC film showed faster recovery rate and less inflammatory response. The results indicate that the platform based on the microfluidic chip provide a rapid, reliable, and repeatable method for wound dressing screening. As an excellent biomaterial for wound healing, the BC film displays different properties on different sides which not only provides a method to optimize the biocompatibility of wound dressings but also paves a new way to building heterogeneous BC-based biomaterials for complex tissue engineering.

Address:Huazhong University of Science and Technology, No. 1037 LuoYu East Road, Hongshan District, Wuhan City, Hubei Province, 
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu Address: College of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu East  


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