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Recent advances in liposome surface modification for oral drug delivery
Date: 2017-06-07
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Essay topic:Recent advances in liposome surface modification for oral drug delivery

Ambit:Functional polymer

Author:Thanh Xuan Nguyen,  Lin Huang, Mario Gauthier, Guang Yang*, Qun Wang*

Key words:bioavailability  liposomes  oral delivery surface  modification  stability

Source:Journal

Specific source :Nanomedicine,2016, 11(9):1169-1185

Published:2016.01

Abstract:

Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration. Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated theraputic agents from the extreme conditions found in the GI tract. Liposomes, with their fluid lipid bilayer membrane and their nanoscale size, can significantly improve oral absorption. Unfortunately, the clinical applications of conventional liposomes have been hindered due to their poor stability and availability under the harsh conditions typically presented in the GI tract. To overcome this problem, the surface modification of liposomes has been investigated. Although liposome surface modification has been extensively studied for oral drug delivery, no review exists so far that adequately covers this topic. The purpose of this paper is to summarize and critically analyze emerging trends in liposome surface modification for oral drug delivery.

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 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu Address: College of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu East  


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