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Enrollment Project
Study on Key Problems of Nano - drug Delivery System and Development of Nanometer Drug Preparation
Date: 2017-03-31
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项目类别:湖北省自然科学基金创新群体项目

项目编号:

项目规模:

参与人员:杨祥良 冯敢生 黄开勋 杨  光 高中洪 郭晓东 张  春 (七名核心成员)

起止时间:2009年 12月至2012 年 12月

项目简介:

      纳米载药系统(NDDS)是当今国际药学界研究前沿之一,也是我国中长期科学和技术发展规划生物医药领域 “重大新药创制”重大专项需重点突破的平台技术。本创新群体发挥多学科交叉优势,针对NDDS的制备表征技术、NDDS的生物药剂学与药代动力学、纳米药物的质量标准与安全性评价等重大关键问题开展创新性研究,揭示NDDS的靶向作用机制、长循环机制、透黏膜作用机制、透血脑屏障(BBB)作用机制、基因转染机制等,阐明纳米粒子的粒径、电荷、亲水亲脂性等表面特性以及靶向因子对纳米药物的吸收、分布、代谢、消除和毒性(ADME-Tox)的影响规律。建立规范的从药物纳米化制备、纳米药物制剂研制和质量标准研究、纳米药物药效学和安全性评价,到纳米药物制剂工程化开发相对完整的技术平台。为国家制定 “纳米药物安全性评价研究规范”、“纳米药物质量标准”、“纳米药物制剂研究规范”等提供依据。开发具有巨大经济效益和影响力的纳米药物制剂,促进我省乃至我国生物医药产业的快速发展。

Study on Key Problems of Nano - drug Delivery System and Development of Nanometer Drug Preparation

 

 

Address:Huazhong University of Science and Technology, No. 1037 LuoYu East Road, Hongshan District, Wuhan City, Hubei Province, 
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu
 Address: Department of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu Address: College of Life Science and Technology, East Campus, Huazhong University of Science and Technology, No. 1037 LuoYu East  


Road, Hongshan District, Wuhan City, Hubei Province, China

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