论文题目：Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride

所属学科：功能高分子

论文作者：Thanh Xuan Nguyen, Lin Huang, Li Liu, Ahmed Mohammed Elamin Abdalla, Mario Gauthier, Guang

关键字：Chitosan, liposome, drug delivery, berberine hydrochloride

论文来源：期刊

具体来源：urnal of Materials Chemistry B, 2014，2（41），7149-7159

发表时间：2014.8

摘要：

Abstract: Berberine hydrochloride (BH) possesses various pharmacological properties including anticancer; unfortunately, it has low oral bioavailability and potential side effects for its parenteral administration. Nanoscale delivery carriers can increase the oral bioavailability of BH. Chitosan has interesting biopharmaceutical properties such as nontoxicity, biocompatibility, biodegradability, and mucoadhesiveness, and the ability to open epithelial tight junctions. This study aims to engineer a chitosan-coated nano-liposomal carrier for the oral delivery of BH. The engineered formulation had a size in the nanoscale range. Chitosan-coated nano-liposomes displayed better stability and slower BH release in the simulated gastrointestinal (GI) environment as compared to the uncoated ones. All values of pharmacokinetic analysis for chitosan-coated nano-liposomes were higher than for uncoated ones. These findings demonstrate that chitosan-coated nano-liposomes are more efficient than uncoated ones for the oral delivery of BH. It can be concluded that the stability and delayed BH release in the simulated GI environment were improved with engineered chitosan-coated nano-liposomes. Moreover, since desirable in vitro and in vivo characteristics were achieved, they are promising release devices for the oral delivery of BH increasing the bioavailability of the drug.